Crank

Release 2006

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Director: Mark Neveldine, Brian Taylor
Stars: Jason Statham, Amy Smart, Jose Pablo Cantillo, Efren Ramirez, Dwight Yoakam
IMDB: http://www.imdb.com/title/tt0479884/

Professional assassin Chev Chelios learns his rival has injected him with a poison that will kill him if his heart rate drops.